Venom allows setting and reading vim options in python through the vim.opt add-in interface. Any option from the official vim documentation can be set. Boolean options take True or False parameters, number options take numbers and string options take strings.
Example:
vim.opt.number = True # show line numbers
print vim.opt.number # prints 'True'
vim.opt.number = not vim.opt.number # toggle options, number is now 'False'
Vim includes a stupendous amount of options, many of which are somewhat niche or not useful for writing plugins. So here is a non-authoritative list of the more generally useful options to give you a quick idea of what’s available. Before using any of these, you should read the full full documentation. This list is intended just as a high level overview.
And here is another list of the intriguing but not immediately useful options for writing plugins. These two lists should cover every options there is (according to the official docs).